Kynurenine 3-monooxygenase
- Kynurenine 3-monooxygenase
In enzymology, a kynurenine 3-monooxygenase (EC number|1.14.13.9) is an enzyme that catalyzes the chemical reaction
:L-kynurenine + NADPH + H+ + O2 ightleftharpoons 3-hydroxy-L-kynurenine + NADP+ + H2O
The 4 substrates of this enzyme are L-kynurenine, NADPH, H+, and O2, whereas its 3 products are 3-hydroxy-L-kynurenine, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating). Other names in common use include kynurenine 3-hydroxylase, kynurenine hydroxylase, and L-kynurenine-3-hydroxylase. This enzyme participates in tryptophan metabolism. It employs one cofactor, FAD.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9029-61-2."
Gene Ontology (GO) codes
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kynurenine 3-monooxygenase — kyn·ure·nine 3 mono·oxy·gen·ase (kīn uґrə nēn″ mon″o okґsĭ jən ās) [EC 1.14.13.9] an enzyme of the oxidoreductase class that catalyzes the hydroxylation of kynurenine as a step in the metabolism of… … Medical dictionary
kynurenine 3-hydroxylase — kyn·ure·nine 3 hy·drox·y·lase (kīn uґrə nēn″ hi drokґsĭ lās) kynurenine 3 monooxygenase … Medical dictionary
kynurenine — A product of the metabolism of l tryptophan, excreted in the urine in small amounts; elevated in cases of vitamin B6 deficiency. k. formamidase SYN: formamidase. k. 3 hydroxylase SYN: k. 3 monooxygenase. k. 3 monooxygenase an enzyme catalyzing… … Medical dictionary
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