- Cyclopentanone monooxygenase
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cyclopentanone monooxygenase Identifiers EC number 1.14.13.16 CAS number 37364-15-1 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a cyclopentanone monooxygenase (EC 1.14.13.16) is an enzyme that catalyzes the chemical reaction
- cyclopentanone + NADPH + H+ + O2
5-valerolactone + NADP+ + H2O
The 4 substrates of this enzyme are cyclopentanone, NADPH, H+, and O2, whereas its 3 products are 5-valerolactone, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing). This enzyme is also called cyclopentanone oxygenase.
References
- Griffin M, Trudgill PW (1972). "The metabolism of cyclopentanol by Pseudomonas N.C.I.B. 9872". Biochem. J. 129 (3): 595–603. PMC 1174162. PMID 4349113. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1174162.
- Griffin M, Trudgill PW (1976). "Purification and properties of cyclopentanone oxygenase of Pseudomonas NCIB 9872". Eur. J. Biochem. 63 (1): 199–209. doi:10.1111/j.1432-1033.1976.tb10222.x. PMID 4313.
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