Dihydrodipicolinate reductase

Dihydrodipicolinate reductase
dihydrodipicolinate reductase
Identifiers
EC number 1.3.1.26
CAS number 9055-46-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dihydrodipicolinate reductase (EC 1.3.1.26) is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ \rightleftharpoons 2,3-dihydrodipicolinate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+, and NADP+, whereas its 4 products are 2,3-dihydrodipicolinate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ oxidoreductase. Other names in common use include dihydrodipicolinic acid reductase, and 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase. This enzyme participates in lysine biosynthesis.

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1ARZ, 1C3V, 1DIH, 1DRU, 1DRV, 1DRW, 1P9L, 1VM6, 1YL5, 1YL6, and 1YL7.

References

  • Farkas W, Gilvarg C (1965). "The reduction step in diaminopimelic acid biosynthesis". J. Biol. Chem. 240 (12): 4717–22. PMID 4378965. 
  • Tamir H (1971). "Dihydrodipicolinic acid reductase (Escherichia coli)". Methods Enzymol. 17B: 134–139. 
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