Cis-2-enoyl-CoA reductase (NADPH)

cis-2-enoyl-CoA reductase (NADPH)
Identifiers
EC number	1.3.1.37
CAS number	72841-00-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a cis-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.37) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NADP⁺ $\rightleftharpoons$ cis-2,3-dehydroacyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are acyl-CoA and NADP⁺, whereas its 3 products are cis-2,3-dehydroacyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ cis-2-oxidoreductase. Other names in common use include NADPH-dependent cis-enoyl-CoA reductase, reductase, cis-2-enoyl coenzyme A, cis-2-enoyl-coenzyme A reductase, and cis-2-enoyl-CoA reductase (NADPH).

References

• H; Nishimaki, T; Shiraishi, T; Kawaguchi, A; Okuda, S; Yamanaka, H (Tokyo). "Studies on the metabolism of unsaturated fatty acids. IX Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli". J. Biochem. (5): 1649–54. PMID 6759504. 

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