GDP-mannose 6-dehydrogenase
- GDP-mannose 6-dehydrogenase
In enzymology, a GDP-mannose 6-dehydrogenase (EC number|1.1.1.132) is an enzyme that catalyzes the chemical reaction
:GDP-D-mannose + 2 NAD+ + H2O GDP-D-mannuronate + 2 NADH + 2 H+
The 3 substrates of this enzyme are GDP-D-mannose, NAD+, and H2O, whereas its 3 products are GDP-D-mannuronate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-D-mannose:NAD+ 6-oxidoreductase. Other names in common use include guanosine diphosphomannose dehydrogenase, GDP-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase, and guanosine diphospho-D-mannose dehydrogenase. This enzyme participates in fructose and mannose metabolism.
tructural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1MFZ, PDB link|1MUU, and PDB link|1MV8.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|37250-63-8."
Gene Ontology (GO) codes
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