DTDP-galactose 6-dehydrogenase

DTDP-galactose 6-dehydrogenase
DTDP-galactose 6-dehydrogenase
Identifiers
EC number 1.1.1.186
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a dTDP-galactose 6-dehydrogenase (EC 1.1.1.186) is an enzyme that catalyzes the chemical reaction

dTDP-D-galactose + 2 NADP+ + H2O \rightleftharpoons dTDP-D-galacturonate + 2 NADPH + 2 H+

The 3 substrates of this enzyme are dTDP-D-galactose, NADP+, and H2O, whereas its 3 products are dTDP-D-galacturonate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-D-galactose:NADP+ 6-oxidoreductase. This enzyme is also called thymidine-diphosphate-galactose dehydrogenase. This enzyme participates in nucleotide sugars metabolism.

References

  • Katan R, Avigad G (1966). "NADP dependent oxidation of TDP-glucose by an enzyme system from sugar beets". Biochem. Biophys. Res. Commun. 24 (1): 18–24. doi:10.1016/0006-291X(66)90403-7. PMID 4381717. 
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