Shikimate dehydrogenase

In enzymology, a shikimate dehydrogenase (EC number|1.1.1.25) is an enzyme that catalyzes the chemical reaction

:shikimate + NADP⁺ $ightleftharpoons$ 3-dehydroshikimate + NADPH + H⁺

Thus, the two substrates of this enzyme are shikimate and NADP⁺, whereas its 3 products are 3-dehydroshikimate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is shikimate:NADP+ 3-oxidoreductase. Other names in common use include dehydroshikimic reductase, shikimate oxidoreductase, shikimate:NADP+ oxidoreductase, 5-dehydroshikimate reductase, shikimate 5-dehydrogenase, 5-dehydroshikimic reductase, DHS reductase, shikimate:NADP+ 5-oxidoreductase, and AroE. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

tructural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1NPD, PDB link|1NVT, PDB link|1NYT, PDB link|1O9B, PDB link|1P74, PDB link|1P77, PDB link|1VI2, PDB link|1WXD, PDB link|2CY0, PDB link|2D5C, PDB link|2EV9, PDB link|2GPT, PDB link|2HK7, PDB link|2HK8, PDB link|2HK9, and PDB link|2NLO.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-87-3."

Gene Ontology (GO) codes