Phenotypic switching

Phenotypic switching

Phenotypic switching (a.k.a. phenotypic dimorphism) is switching between two cell-types. An example is Candida albicans, which, when it infects host tissue, switches from the usual unicellular yeast-like form of into an invasive, multicellular filamentous form. [cite journal |author=Kumamoto CA, Vinces MD |title=Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence |journal=Cell. Microbiol. |volume=7 |issue=11 |pages=1546–54 |year=2005 |pmid=16207242 |doi=10.1111/j.1462-5822.2005.00616.x] This switching between two cell-types is known as dimorphism.

Phenotypic switching in C.albicans include the switch from white cells to opaque cells in need for sexual mating.

References

External links

* [http://www.endocrine-abstracts.org/ea/0002/ea0002p52.htm Endocrine Abstracts] "Are Hox genes responsible for the phenotypic switching and zonation of the adult adrenal cortex?"

* [http://www.jci.org/cgi/content/full/108/11/1577 American Society for Clinical Investigation] "Phenotypic switching in the fungal pathogen Cryptococcus neoformans"

* [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=96790 American Society for Microbiology] "Control of White-Opaque Phenotypic Switching in Candida albicans by the Efg1p Morphogenetic Regulator"

* [http://www.aegis.com/conferences/croi/1997/450.html Conference on Retroviruses and Opportunistic Infections] "Repeated phenotypic switching of HIV-1 in AIDS patients sampled regularly over 2 years."


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