N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide
N,N'-Diisopropylcarbodiimide
Identifiers
Abbreviations DIPC
CAS number 693-13-0
PubChem 12734
Jmol-3D images Image 1
Properties
Molecular formula C7H14N2
Molar mass 126.2 g mol−1
Appearance Liquid
Density 0.806 g/mL
Boiling point

145-148 °C

Hazards
MSDS External MSDS
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

N,N′-Diisopropylcarbodiimide is a carbodiimide used in peptide synthesis. As a liquid, it is easier to handle than the commonly used N,N′-dicyclohexylcarbodiimide.

Further reading

  • Angell, Y (1994). "Comparative studies of the coupling of N-methylated, sterically hindered amino acids during solid-phase peptide synthesis". Tetrahedron Lett. 35 (33): 5981. doi:10.1016/0040-4039(94)88054-9. 
  • Izdebski, JAN; Orlowska, Alicja; Anulewicz, Romana; Witkowska, EWA; Fiertek, Dariusz (1994). "Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides : Isolation of two N-acylureas". Int. J. Pept. Protein Res. 43 (2): 184. doi:10.1111/j.1399-3011.1994.tb00521.x.