Brallobarbital

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IUPAC_name = 5-(2-bromoprop-2-enyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
synonyms = Brallobarbital, Vesparax


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CAS_number = 561-86-4
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PubChem = 68416
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C = 10 | H = 11 | Br = 1 | N = 2 | O = 3
molecular_weight = 287.11 g/mol
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Brallobarbital is a barbiturate derivative invented in 1964. It has sedative and hypnotic properties, and was used for the treatment of insomnia. Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg brallobarbital and 50 mg hydroxyzine. [Lhermann J. Clinical application of a new very active hypnotic associating sodium secobarbital, calcium brallobarbital and hydroxyzine (UC-8130). Gazette Medicale de France. 1964 Mar 10;71:961-2. (French)] The long half-life of this combination of drugs tended to cause a hangover effect the next day, [Yih TD, Rossum JM. Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Xenobiotica. 1976 Jun;6(6):355-62.] and Vesparax fell into disuse once newer drugs with less side effects had been developed. [Fischbach R. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. British Journal of Clinical Pharmacology. 1983;16 Suppl 1:167S-171S.]

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