Clofoctol

Clofoctol

Systematic (IUPAC) name
2-[(2,4-dichlorophenyl)methyl]- 4-(2,4,4-trimethylpentan-2-yl)phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Rectal (suppository)[1][2]
Pharmacokinetic data
Bioavailability	98%[1]
Metabolism	Hepatic glucuronidation[1]
Excretion	Biliary[1]
Identifiers
CAS number	37693-01-9
ATC code	J01XX03
PubChem	CID 2799
ChemSpider	2697 Y
UNII	704083NI0R Y
KEGG	D07244 Y
Chemical data
Formula	C21H26Cl2O
Mol. mass	365.336 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3 Y Key:HQVZOORKDNCGCK-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.^[1][2]

It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.^[3]

It penetrates into human lung tissue.^[4]

References

1. ^ ^{a b c d e} "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm. Retrieved 2007-08-10. 
2. ^ ^{a b} "Clofoctol" (in French). BIAM. July 16, 1999. http://www.biam2.org/www/Sub3508.html. Retrieved 2007-08-10. 
3. ^ Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]" (in French). J Pharmacol 11 (4): 411–25. PMID 6782374. 
4. ^ Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res 14 (1): 39–43. PMID 3391105.