Transcript of unknown function
- Transcript of unknown function
Transcripts of unknown function (TUFs) is the name that has been suggested for known RNA transcripts of DNA whose function is unclear. Most TUFs are probably ncRNAs, such as RNAi or snoRNAs, but could also represent a whole new class of ncRNA.[ cite journal | last = Gingeras | first = Thomas R. | year = 2007 | title = Origin of phenotypes: Genes and transcripts | journal = Genome Research | volume = 17| issue = 6 | pages = 682–690 | doi = 10.1101/gr.6525007 | pmid = 17567989 ] The DNA sequences for TUFs reside in the intergenic or intronic regions of the genome, which is often called junk DNA. This currently makes up much of the human genome, although the percentage of the genome that falls under the TUFs category is likely to go down significantly as more progress is made towards understanding the many roles of RNA.] Categories of TUFs
Broadly speaking, TUFs can be classified into three categories:
1. TUFs that are complementary to sense transcripts of protein-coding genes
2. TUFs that are novel isoform transcripts of protein-coding genes; this can include expressed pseudogenes
3. TUFs that reside on the same strand as protein-coding genes in the intronic region or entirely in the intergenic region Other information
There are very few details known about TUFs, which is why the phrase even exists, but one thing that has been shown several times is that they are not very conserved between mice and humans. This could be due to a number of factors, including more recent evolution in the primate lineage or extensive post-transcriptional modification of the RNA. References
Wikimedia Foundation.
2010.
Look at other dictionaries:
C11orf73 — chromosome 11 open reading frame 73 [[file:|border|250px|alt=]] A Phyre homology model of the human C11orf73 protein.[1] Identifiers Symbols … Wikipedia
Eukaryotic chromosome fine structure — refers to the structure of sequences for eukaryotic chromosomes. Some fine sequences are included in more than one class, so the classification listed is not intended to be completely separate.Chromosomal characteristicsSome sequences are… … Wikipedia
RNA interference — (RNAi) is a mechanism that inhibits gene expression at the stage of translation or by hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons (significant for some forms of innate immune response), and … Wikipedia
Estrogen receptor — 1 (ER alpha) A dimer of the ligand binding region of ERα (PDB rendering based on 3erd). Identifi … Wikipedia
Chimpanzee genome project — The Chimpanzee Genome Project is an effort to determine the DNA sequence of the Chimpanzee genome. It is expected that by comparing the genomes of humans and other apes, it will be possible to better understand what makes humans distinct from… … Wikipedia
CAPN10 — Calpain 10, also known as CAPN10, is a human gene. PBB Summary section title = summary text = Calpains are ubiquitous, well conserved family of calcium dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an… … Wikipedia
Mir-BART1 microRNA precursor family — The mir BART1 microRNA precursor is found in Human herpesvirus 4 (Epstein Barr virus) and Cercopithicine herpesvirus 15. mir BART1 is found in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein Barr… … Wikipedia
Mir-BART2 microRNA precursor family — The mir BART2 microRNA precursor found in Human herpesvirus 4 (Epstein Barr virus) and Cercopithicine herpesvirus 15. mir BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein Barr… … Wikipedia
C3orf60 — Chromosome 3 open reading frame 60, also known as C3orf60, is a human gene.cite web | title = Entrez Gene: C3orf60 chromosome 3 open reading frame 60| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=25915|… … Wikipedia
OLE RNA — Ornate Large Extremophilic RNA Predicted secondary structure and sequence conservation of OLE Identifiers Symbol OLE Rfam … Wikipedia
