CAPN10

Calpain 10, also known as CAPN10, is a human gene.

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summary_text = Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: CAPN10 calpain 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11132| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sorimachi H, Ishiura S, Suzuki K |title=Structure and physiological function of calpains. |journal=Biochem. J. |volume=328 ( Pt 3) |issue= |pages= 721–32 |year= 1998 |pmid= 9396712 |doi=
*cite journal | author=Cox NJ, Hayes MG, Roe CA, "et al." |title=Linkage of calpain 10 to type 2 diabetes: the biological rationale. |journal=Diabetes |volume=53 Suppl 1 |issue= |pages= S19–25 |year= 2004 |pmid= 14749261 |doi=
*cite journal | author=Turner MD, Cassell PG, Hitman GA |title=Calpain-10: from genome search to function. |journal=Diabetes Metab. Res. Rev. |volume=21 |issue= 6 |pages= 505–14 |year= 2006 |pmid= 16028216 |doi= 10.1002/dmrr.578
*cite journal | author=Horikawa Y |title=Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes. |journal=Endocr. J. |volume=53 |issue= 5 |pages= 567–76 |year= 2007 |pmid= 16873988 |doi=
*cite journal | author=Horikawa Y, Oda N, Cox NJ, "et al." |title=Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. |journal=Nat. Genet. |volume=26 |issue= 2 |pages= 163–75 |year= 2000 |pmid= 11017071 |doi= 10.1038/79876
*cite journal | author=Baier LJ, Permana PA, Yang X, "et al." |title=A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. |journal=J. Clin. Invest. |volume=106 |issue= 7 |pages= R69–73 |year= 2000 |pmid= 11018080 |doi=
*cite journal | author=Nagase T, Nakayama M, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=
*cite journal | author=Ma H, Fukiage C, Kim YH, "et al." |title=Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28525–31 |year= 2001 |pmid= 11375982 |doi= 10.1074/jbc.M100603200
*cite journal | author=Evans JC, Frayling TM, Cassell PG, "et al." |title=Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 544–52 |year= 2001 |pmid= 11481585 |doi=
*cite journal | author=Tsai HJ, Sun G, Weeks DE, "et al." |title=Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association. |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1236–44 |year= 2002 |pmid= 11704924 |doi=
*cite journal | author=Woollard JR, Rothschild MF |title=Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26. |journal=Anim. Genet. |volume=32 |issue= 6 |pages= 393 |year= 2002 |pmid= 11736815 |doi=
*cite journal | author=Xiang K, Fang Q, Zheng T, "et al." |title= [The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=18 |issue= 6 |pages= 426–30 |year= 2002 |pmid= 11774208 |doi=
*cite journal | author=Elbein SC, Chu W, Ren Q, "et al." |title=Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 2 |pages= 650–4 |year= 2002 |pmid= 11836299 |doi=
*cite journal | author=Daimon M, Oizumi T, Saitoh T, "et al." |title=Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese. |journal=Diabetes Res. Clin. Pract. |volume=56 |issue= 2 |pages= 147–52 |year= 2002 |pmid= 11891023 |doi=
*cite journal | author=Fullerton SM, Bartoszewicz A, Ybazeta G, "et al." |title=Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1096–106 |year= 2002 |pmid= 11891618 |doi=
*cite journal | author=Hoffstedt J, Rydén M, Löfgren P, "et al." |title=Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells. |journal=Diabetologia |volume=45 |issue= 2 |pages= 276–82 |year= 2002 |pmid= 11935160 |doi= 10.1007/s00125-001-0732-2
*cite journal | author=Malecki MT, Moczulski DK, Klupa T, "et al." |title=Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population. |journal=Eur. J. Endocrinol. |volume=146 |issue= 5 |pages= 695–9 |year= 2002 |pmid= 11980626 |doi=
*cite journal | author=Sun HX, Zhang KX, Du WN, "et al." |title=Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China. |journal=Biomed. Environ. Sci. |volume=15 |issue= 1 |pages= 75–82 |year= 2002 |pmid= 12046551 |doi=
*cite journal | author=Haddad L, Evans JC, Gharani N, "et al." |title=Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2606–10 |year= 2002 |pmid= 12050223 |doi=

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