Complexin is a cytoplasmic nerve tissue protein which binds to the SNARE protein complex (SNAREpin) with a high affinity. The transport vesicle protein synaptotagmin, among others, in the presence of Ca2+, displaces complexin allowing the SNARE protein complex to bind the transport vesicle to the presynaptic membrane, although the precise mechanism remains unknown. Complexin acts both as an inhibitor and a facilitator of vesicle fusion and neurotransmitter release at the synapse. In one conformation, it clamps SNAREpin complexes, preventing vesicle fusion, while in a different conformation it releases the SNAREpins, allowing synaptotagmin to trigger fusion. [1] This makes complexin a critical gatekeeper in the synaptic vesicle fusion process.
complexin — noun A type of protein found in nerve tissue … Wiktionary
CPLX2 — Complexin 2, also known as CPLX2, is a human gene.cite web | title = Entrez Gene: CPLX2 complexin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10814| accessdate = ] PBB Summary section title = summary… … Wikipedia
CPLX1 — Complexin 1, also known as CPLX1, is a human gene.cite web | title = Entrez Gene: CPLX1 complexin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10815| accessdate = ] PBB Summary section title = summary… … Wikipedia
STX1A — Syntaxin 1A (brain) PDB rendering based on 1br0 … Wikipedia
Synaptotagmin — Synaptotagmins ( isotypes Syt1 Syt13 ) constitute a family of membrane trafficking proteins that are characterized by an N terminal transmembrane region (TMR), a variable linker, and two C terminal C2 domains C2A and C2B. FunctionsSynaptotagmin… … Wikipedia
Synaptotagmine — Der molekulare Mechanismus, der die Exozytose bei der Freisetzung von Neurotransmitter reguliert. Synaptotagmine sind eine Gruppe von 15 an Zellmembranen lokalisierten Proteinen, die sich durch eine N terminale Transmembranregion (TMR), eine… … Deutsch Wikipedia
STX2 — Syntaxin 2, also known as STX2, is a human gene.cite web | title = Entrez Gene: STX2 syntaxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2054| accessdate = ] PBB Summary section title = summary text … Wikipedia
SLC17A7 — Solute carrier family 17 (sodium dependent inorganic phosphate cotransporter), member 7, also known as SLC17A7, is a human gene.cite web | title = Entrez Gene: SLC17A7 solute carrier family 17 (sodium dependent inorganic phosphate cotransporter) … Wikipedia
Synapse — Synapsen (Einzahl die Synapse, von gr. σύν, syn = zusammen, ἅπτειν, haptein = ergreifen, fassen, tasten) sind Kontaktstellen zwischen Nervenzellen und anderen Zellen (wie Sinnes , Muskel oder Drüsenzellen) oder zwischen Nervenzellen untereinander … Deutsch Wikipedia
Synapsen — (gr. σύν, syn = zusammen, ἅπτειν, haptein = ergreifen, fassen, tasten) sind Kontaktstellen zwischen Nervenzellen und anderen Zellen (wie Sinnes , Muskel oder Drüsenzellen) oder zwischen Nervenzellen untereinander. An ihnen findet die… … Deutsch Wikipedia
