Reductive acetyl-CoA pathway
- Reductive acetyl-CoA pathway
The reductive acetyl CoA Pathway is a method of fixing organic carbon from carbon dioxide used by some bacteria and archaea. It is also know as the Wood Ljungdahl Pathway.
The principle reactions take the form of converting CO2 via intermediates to acetyl Coenzyme A. Intermediates include carbon monoxide and CH3CO-.
There are two parallel reactions initially::CO2 + H2 → Formic Acid → X-CH3:CO2 + H2 → H2O + COThen these come together with CoEnzyme-A to form acetyl coenzyme A.The steps are catalysed by enzymes at each step [cite journal
author=Ragsdale SW.
title=Enzymology of the acetyl-CoA pathway of CO2 fixation
journal=Crit Rev Biochem Mol Biol.
year=1991
volume=26
issue=3-4
pages=261–300
pmid=1935170
doi=10.3109/10409239109114070 ] .
It is found in various archaean methanogens and in acetate producing bacteria such as "Clostridium".
Unlike the Reverse Krebs cycle and the Calvin cycle, this process is not cyclic.
ee also
* Carbon fixation
References
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