Small Cajal body-specific RNA 17
- Small Cajal body-specific RNA 17
scaRNAs are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12 [1] . The complete human U12-22/U4-8 scaRNA is composed of two tandem C/D box domains (termed U12-22 and U4-8). The 5' and 3' C/D domains are predicted to guide the 2'O-ribose methylation of residue U22 in U12 ( [http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00007 RF00007] ) and residue C8 in U4 ( [http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00015 RF00015] ) snRNAs respectively [1] . This family only includes only the 5' C/D box domain (U12-22) as the 3' C/D box is represented by [http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00283 RF00283] . The 3' C/D domain (U4-8) was also cloned previously by Darzacq [2] and called U91. Both the doublet (U12-22/U4-8) and singlet (U4-8) forms of this snRNA have been purified from Hela cells [1] . The doublet form U12-22/U4-8 has been shown to localise to the nucleoplasm and is proposed to reside in the Cajal bodies whereas the U4-8 single domain appears to accumulate in the nucleolus [1] . In humans the genomic location of U12-88/U4-8 is intergenic and the purified transcript has been shown to possess a methylated guanosine cap suggesting it is independently transcribed by RNA pol II [1] .
References
* [1] cite journal | last = Tycowski | first = KT | coauthors = Aab A, Steitz JA | year = 2004 | title = Guide RNAs with 5' Caps and Novel Box C/D snoRNA-like Domains for Modification of snRNAs in Metazoa | journal = Curr Biol | volume = 14 | pages = 1985–1995 | pmid = 15556860 | doi = 10.1016/j.cub.2004.11.003
* [2] cite journal | last = Darzacq | first = X | coauthors = Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T | year = 2002 | title = Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs | journal = EMBO J. | volume = 21 | pages = 2746–2756 | pmid = 12032087 | doi = 10.1093/emboj/21.11.2746
* [3] cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002
External links
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Small Cajal body-specific RNA — Small Cajal body specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) which specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs or snurps). ScaRNAs… … Wikipedia
Small Cajal body specific RNA 6 — (also known as SCARNA6 or U88) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U5 spliceosomal RNA.scaRNAs are a specific class of small nucleolar… … Wikipedia
Small Cajal body specific RNA 23 — (also known as SCARNA23 or ACA11) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 15 — (also known as SCARNA15 or ACA45) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 16 — (also known as SCARNA16 or ACA47) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 24 — (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 8 — (also known as SCARNA8 or U92) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U2 spliceosomal RNA.scaRNAs are a specific class of small nucleolar… … Wikipedia
Small Cajal body-specific RNA 18 — (also known as U91 or U4 8) is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12cite journal | author = Darzacq X, Jády … Wikipedia
Small Cajal body specific RNA 25 — (otherwise known as scaRNA25, HBI 100, MBI 100 and MBI 114) is a scaRNA which are a class of ncRNAs characterised as a small nuclear RNAs localised to the Cajal bodies [cite journal | last = Darzacq | first = X | coauthors = Jady BE, Verheggen C … Wikipedia
Small Cajal body specific RNA 13 — In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA. scaRNAs are a specific class … Wikipedia
Small Cajal body specific RNA 20 — In molecular biology, Small Cajal body specific RNA 20 (also known as scaRNA20 or ACA66) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA. scaRNAs are a specific… … Wikipedia
