Coronavirus frameshifting stimulation element

Coronavirus frameshifting stimulation element
Predicted secondary structure and sequence conservation of Corona_FSE
Identifiers
Symbol	Corona_FSE
Rfam	RF00507
Other data
RNA type	Cis-reg; frameshift_element
Domain(s)	Viruses
SO	0000233

In molecular biology, the coronavirus frameshifting stimulation element is a conserved stem-loop of RNA found in coronaviruses that can promote ribosomal frameshifting. Such RNA molecules interact with a downstream region to form a pseudoknot structure; the region varies according to the virus but pseudoknot formation is known to stimulate frameshifting. In the classical situation, a sequence 32 nucleotides downstream of the stem is complementary to part of the loop. In other coronaviruses, however, another stem-loop structure around 150 nucleotides downstream can interact with members of this family to form kissing stem loops and stimulate frameshifting.^[1]

Other RNA families identified in the coronavirus include the SL-III cis-acting replication element (CRE), the coronavirus 3' stem-loop II-like motif (s2m), the coronavirus packaging signal and the coronavirus 3' UTR pseudoknot.

References

1. ^ Baranov, PV; Henderson CM, Anderson CB, Gesteland RF, Atkins JF, Howard MT (2005). "Programmed ribosomal frameshifting in decoding the SARS-CoV genome". Virology 332 (2): 498–510. doi:10.1016/j.virol.2004.11.038. PMID 15680415. 

External links

• Rfam page for Coronavirus frameshifting stimulation element