Coronavirus 3' UTR pseudoknot

Coronavirus 3' UTR pseudoknot
Predicted secondary structure and sequence conservation of Corona_pk3
Identifiers
Symbol	Corona_pk3
Rfam	RF00165
Other data
RNA type	Cis-reg
Domain(s)	Viruses
SO	0000205

The Coronavirus 3' UTR pseudoknot is an RNA structure found in the coronavirus genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genomes. The 3' UTR region of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot structure which is necessary for viral genome replication.^[1] The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.

Other RNA families identified in the coronavirus include the coronavirus SL-III cis-acting replication element (CRE), the coronavirus frameshifting stimulation element, the coronavirus 3' stem-loop II-like motif (s2m) and the coronavirus packaging signal.

References

1. ^ Williams, GD; Chang RY, Brian DA (1999). "A phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication". J Virol 73 (10): 8349–8355. PMC 112852. PMID 10482585. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=112852. 

External links

• Rfam page for Coronavirus 3' UTR pseudoknot