Inositol triphosphate receptor
- Inositol triphosphate receptor
protein
Name = inositol 1,4,5-triphosphate receptor, type 1
caption =
width =
HGNCid = 6180
Symbol = ITPR1
AltSymbols =
EntrezGene = 3708
OMIM = 147265
RefSeq = NM_002222
UniProt = Q14643
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 26.1
LocusSupplementaryData = protein
Name = inositol 1,4,5-triphosphate receptor, type 2
caption =
width =
HGNCid = 6181
Symbol = ITPR2
AltSymbols =
EntrezGene = 3709
OMIM = 600144
RefSeq = NM_002223
UniProt = Q14571
PDB =
ECnumber =
Chromosome = 12
Arm = p
Band = 11.23
LocusSupplementaryData = protein
Name = inositol 1,4,5-triphosphate receptor, type 3
caption =
width =
HGNCid = 6182
Symbol = ITPR3
AltSymbols =
EntrezGene = 3710
OMIM = 147267
RefSeq = NM_002224
UniProt = Q14573
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21.31
LocusSupplementaryData =
Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3). The IP3 receptor was first purified from rat cerebellum [ [http://www.ncbi.nlm.nih.gov/pubmed/17429043?dopt=Citation Inositol trisphosphate receptor Ca2+ release chann... [Physiol Rev. 2007 - PubMed Result ] ] .
Distribution
It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.
tructure
The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.
ee also
* inositol
* inositol phosphate
** inositol monophosphate
** inositol triphosphate
** inositol pentakisphosphate
** inositol hexaphosphate
References
External links
*
Wikimedia Foundation.
2010.
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