Erbin (protein)

Discovered in 1997, Erbin is a 200kDa protein containing a PDZ domain. [cite journal | author = Borg JP, Marchetto S. "et al."| title = ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor | journal = Nat. Cell. Biol. | year=2000 | volume=2 | issue=7 | pages=407–414 | pmid = 10878805| doi = 10.1038/35017038 ] Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis. [cite journal | author = Kolch, W. | title = Erbin: sorting out ErbB2 receptors or giving Ras a break? | journal = Sci. STKE. | year=2003 | volume=199 | pages=pe37 | pmid = 12966186 ] Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein. [cite journal | author = Dai P, Xiong WC, and Mei L. | title = Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex | journal = J. Biol. Chem. | year=2006 | volume=281 | issue=2 | pages=927–933 | pmid = 16301319 | doi = 10.1074/jbc.M507360200]

Erbin is named after its ability to bind ErbB2, though it shares a name with Saint Erbin, a 5th century Cornish monk. This has led some to suggest that Saint Erbin may be the patron saint of both PDZ domains and ErbB protein kinase receptors.

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