PICK1

PICK1

Protein interacting with PRKCA 1, also known as PICK1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: PICK1 protein interacting with PRKCA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9463| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Collingridge GL, Isaac JT |title=Functional roles of protein interactions with AMPA and kainate receptors. |journal=Neurosci. Res. |volume=47 |issue= 1 |pages= 3–15 |year= 2003 |pmid= 12941441 |doi=
*cite journal | author=Staudinger J, Zhou J, Burgess R, "et al." |title=PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. |journal=J. Cell Biol. |volume=128 |issue= 3 |pages= 263–71 |year= 1995 |pmid= 7844141 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Staudinger J, Lu J, Olson EN |title=Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32019–24 |year= 1998 |pmid= 9405395 |doi=
*cite journal | author=Torres R, Firestein BL, Dong H, "et al." |title=PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. |journal=Neuron |volume=21 |issue= 6 |pages= 1453–63 |year= 1999 |pmid= 9883737 |doi=
*cite journal | author=Dev KK, Nishimune A, Henley JM, Nakanishi S |title=The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. |journal=Neuropharmacology |volume=38 |issue= 5 |pages= 635–44 |year= 1999 |pmid= 10340301 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Takeya R, Takeshige K, Sumimoto H |title=Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 149–55 |year= 2000 |pmid= 10623590 |doi= 10.1006/bbrc.1999.1932
*cite journal | author=Cowan CA, Yokoyama N, Bianchi LM, "et al." |title=EphB2 guides axons at the midline and is necessary for normal vestibular function. |journal=Neuron |volume=26 |issue= 2 |pages= 417–30 |year= 2000 |pmid= 10839360 |doi=
*cite journal | author=Dev KK, Nakajima Y, Kitano J, "et al." |title=PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. |journal=J. Neurosci. |volume=20 |issue= 19 |pages= 7252–7 |year= 2001 |pmid= 11007882 |doi=
*cite journal | author=Lin WJ, Chang YF, Wang WL, Huang CY |title=Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. |journal=Biochem. J. |volume=354 |issue= Pt 3 |pages= 635–43 |year= 2001 |pmid= 11237868 |doi=
*cite journal | author=Jaulin-Bastard F, Saito H, Le Bivic A, "et al." |title=The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15256–63 |year= 2001 |pmid= 11278603 |doi= 10.1074/jbc.M010032200
*cite journal | author=Torres GE, Yao WD, Mohn AR, "et al." |title=Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. |journal=Neuron |volume=30 |issue= 1 |pages= 121–34 |year= 2001 |pmid= 11343649 |doi=
*cite journal | author=Lin SH, Arai AC, Wang Z, "et al." |title=The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. |journal=Mol. Pharmacol. |volume=60 |issue= 5 |pages= 916–23 |year= 2001 |pmid= 11641419 |doi=
*cite journal | author=Duggan A, Garcia-Anoveros J, Corey DP |title=The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5203–8 |year= 2002 |pmid= 11739374 |doi= 10.1074/jbc.M104748200
*cite journal | author=Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ |title=Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 443–50 |year= 2002 |pmid= 11802773 |doi=
*cite journal | author=Hirbec H, Perestenko O, Nishimune A, "et al." |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221–4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200
*cite journal | author=Perroy J, El Far O, Bertaso F, "et al." |title=PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. |journal=EMBO J. |volume=21 |issue= 12 |pages= 2990–9 |year= 2002 |pmid= 12065412 |doi= 10.1093/emboj/cdf313
*cite journal | author=Chen T, Ueda Y, Xie S, Li E |title=A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38746–54 |year= 2002 |pmid= 12138111 |doi= 10.1074/jbc.M205312200

External links

* [http://www.genecards.org/cgi-bin/carddisp.pl?gene=PICK1&search=PICK1 Genecards]
* [http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:894645 MGI]

PBB_Controls
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update_protein_box = yes
update_summary = yes
update_citations = yes


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