ERBB2IP

Erbb2 interacting protein, also known as ERBB2IP, is a human gene.cite web | title = Entrez Gene: ERBB2IP erbb2 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55914| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.cite web | title = Entrez Gene: ERBB2IP erbb2 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55914| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Kolch W |title=Erbin: sorting out ErbB2 receptors or giving Ras a break? |journal=Sci. STKE |volume=2003 |issue= 199 |pages= pe37 |year= 2003 |pmid= 12966186 |doi= 10.1126/stke.2003.199.pe37
*cite journal | author=Nagase T, Ishikawa K, Kikuno R, "et al." |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=
*cite journal | author=Borg JP, Marchetto S, Le Bivic A, "et al." |title=ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 7 |pages= 407–14 |year= 2000 |pmid= 10878805 |doi= 10.1038/35017038
*cite journal | author=Jaulin-Bastard F, Saito H, Le Bivic A, "et al." |title=The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15256–63 |year= 2001 |pmid= 11278603 |doi= 10.1074/jbc.M010032200
*cite journal | author=Huang YZ, Wang Q, Xiong WC, Mei L |title=Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19318–26 |year= 2001 |pmid= 11279080 |doi= 10.1074/jbc.M100494200
*cite journal | author=Favre B, Fontao L, Koster J, "et al." |title=The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32427–36 |year= 2001 |pmid= 11375975 |doi= 10.1074/jbc.M011005200
*cite journal | author=Saito H, Santoni MJ, Arsanto JP, "et al." |title=Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32051–5 |year= 2001 |pmid= 11440998 |doi= 10.1074/jbc.C100330200
*cite journal | author=Jaulin-Bastard F, Arsanto JP, Le Bivic A, "et al." |title=Interaction between Erbin and a Catenin-related protein in epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2869–75 |year= 2002 |pmid= 11711544 |doi= 10.1074/jbc.M109652200
*cite journal | author=Laura RP, Witt AS, Held HA, "et al." |title=The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12906–14 |year= 2002 |pmid= 11821434 |doi= 10.1074/jbc.M200818200
*cite journal | author=Izawa I, Nishizawa M, Tomono Y, "et al." |title=ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells. |journal=Genes Cells |volume=7 |issue= 5 |pages= 475–85 |year= 2002 |pmid= 12047349 |doi=
*cite journal | author=Ohno H, Hirabayashi S, Iizuka T, "et al." |title=Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells. |journal=Oncogene |volume=21 |issue= 46 |pages= 7042–9 |year= 2002 |pmid= 12370826 |doi= 10.1038/sj.onc.1205852
*cite journal | author=Huang YZ, Zang M, Xiong WC, "et al." |title=Erbin suppresses the MAP kinase pathway. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 1108–14 |year= 2003 |pmid= 12379659 |doi= 10.1074/jbc.M205413200
*cite journal | author=Birrane G, Chung J, Ladias JA |title=Novel mode of ligand recognition by the Erbin PDZ domain. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1399–402 |year= 2003 |pmid= 12444095 |doi= 10.1074/jbc.C200571200
*cite journal | author=Skelton NJ, Koehler MF, Zobel K, "et al." |title=Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7645–54 |year= 2003 |pmid= 12446668 |doi= 10.1074/jbc.M209751200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Warner DR, Pisano MM, Roberts EA, Greene RM |title=Identification of three novel Smad binding proteins involved in cell polarity. |journal=FEBS Lett. |volume=539 |issue= 1-3 |pages= 167–73 |year= 2003 |pmid= 12650946 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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