CD94

CD94

CD94 (Cluster of Differentiation 16b) , also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.cite web | title = Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3824| accessdate = ]

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

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summary_text = Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.cite web | title = Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3824| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chang C, Rodríguez A, Carretero M, "et al." |title=Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2433–7 |year= 1995 |pmid= 7589107 |doi=
*cite journal | author=Moretta A, Vitale M, Sivori S, "et al." |title=Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. |journal=J. Exp. Med. |volume=180 |issue= 2 |pages= 545–55 |year= 1994 |pmid= 8046333 |doi=
*cite journal | author=Phillips JH, Chang C, Mattson J, "et al." |title=CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. |journal=Immunity |volume=5 |issue= 2 |pages= 163–72 |year= 1996 |pmid= 8769479 |doi=
*cite journal | author=Lazetic S, Chang C, Houchins JP, "et al." |title=Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. |journal=J. Immunol. |volume=157 |issue= 11 |pages= 4741–5 |year= 1996 |pmid= 8943374 |doi=
*cite journal | author=Brooks AG, Posch PE, Scorzelli CJ, "et al." |title=NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. |journal=J. Exp. Med. |volume=185 |issue= 4 |pages= 795–800 |year= 1997 |pmid= 9034158 |doi=
*cite journal | author=Mandelboim O, Pazmany L, Davis DM, "et al." |title=Multiple receptors for HLA-G on human natural killer cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14666–70 |year= 1998 |pmid= 9405670 |doi=
*cite journal | author=Rodríguez A, Carretero M, Glienke J, "et al." |title=Structure of the human CD94 C-type lectin gene. |journal=Immunogenetics |volume=47 |issue= 4 |pages= 305–9 |year= 1998 |pmid= 9472066 |doi=
*cite journal | author=Le Dréan E, Vély F, Olcese L, "et al." |title=Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 264–76 |year= 1998 |pmid= 9485206 |doi=
*cite journal | author=Braud VM, Allan DS, O'Callaghan CA, "et al." |title=HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. |journal=Nature |volume=391 |issue= 6669 |pages= 795–9 |year= 1998 |pmid= 9486650 |doi= 10.1038/35869
*cite journal | author=Plougastel B, Trowsdale J |title=Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. |journal=Genomics |volume=49 |issue= 2 |pages= 193–9 |year= 1998 |pmid= 9598306 |doi= 10.1006/geno.1997.5197
*cite journal | author=Furukawa H, Yabe T, Watanabe K, "et al." |title=An alternatively spliced form of the human CD94 gene. |journal=Immunogenetics |volume=48 |issue= 1 |pages= 87–8 |year= 1998 |pmid= 9601951 |doi=
*cite journal | author=Lanier LL, Corliss B, Wu J, Phillips JH |title=Association of DAP12 with activating CD94/NKG2C NK cell receptors. |journal=Immunity |volume=8 |issue= 6 |pages= 693–701 |year= 1998 |pmid= 9655483 |doi=
*cite journal | author=Vance RE, Kraft JR, Altman JD, "et al." |title=Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). |journal=J. Exp. Med. |volume=188 |issue= 10 |pages= 1841–8 |year= 1999 |pmid= 9815261 |doi=
*cite journal | author=Brooks AG, Borrego F, Posch PE, "et al." |title=Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. |journal=J. Immunol. |volume=162 |issue= 1 |pages= 305–13 |year= 1999 |pmid= 9886400 |doi=
*cite journal | author=Boyington JC, Riaz AN, Patamawenu A, "et al." |title=Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. |journal=Immunity |volume=10 |issue= 1 |pages= 75–82 |year= 1999 |pmid= 10023772 |doi=
*cite journal | author=Bellón T, Heredia AB, Llano M, "et al." |title=Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 3996–4002 |year= 1999 |pmid= 10201920 |doi=
*cite journal | author=Ding Y, Sumitran S, Holgersson J |title=Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells. |journal=Scand. J. Immunol. |volume=49 |issue= 5 |pages= 459–65 |year= 1999 |pmid= 10320637 |doi=
*cite journal | author=Romero P, Ortega C, Palma A, "et al." |title=Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation. |journal=J. Leukoc. Biol. |volume=70 |issue= 2 |pages= 219–24 |year= 2001 |pmid= 11493613 |doi=
*cite journal | author=Shum BP, Flodin LR, Muir DG, "et al." |title=Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 240–52 |year= 2002 |pmid= 11751968 |doi=
*cite journal | author=Terrazzano G, Zanzi D, Palomba C, "et al." |title=Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors. |journal=J. Leukoc. Biol. |volume=72 |issue= 2 |pages= 305–11 |year= 2002 |pmid= 12149421 |doi=

External links

*

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