Secretoglobin, family 1A, member 1 (uteroglobin)

The founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals.cite journal | author = Laukaitis CM, Karn RC | title = Evolution of the secretoglobins: a genomic and proteomic view | journal = Biological Journal of the Linnean Society | volume = 84 | issue = 3 | pages = 493–501 | year = 2005 | pmid = | doi = 10.1111/j.1095-8312.2005.00450.x | issn = ] This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: Uteroglobin (UG, UGB), Uteroglobin-like Antigen (UGL), Blastokinin, Clara cell secretory protein (CCSP), Clara cell 16 kD protein (17 in rat/mice), Clara Cell-Specific 10 kD Protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human Clara Cell Phospholipid-Binding Protein (hCCPBP), Secretoglobin 1A member 1 (SCGB1A1).cite journal | author = Klug J, Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G | title = Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report | journal = Ann. N. Y. Acad. Sci. | volume = 923 | issue = | pages = 348–54 | year = 2000 | pmid = 11193777 | doi = 10.1111/j.1095-8312.2005.00450.x | issn = ]

Function

Real physiological role is not known. Putative functions are:
# Immunomodulation:
# Progesterone binding: weak in some animals, especially weak in humans. (Note: UGB is itself progesterone induced gene in the endometrium.)
# Inhibits phospholipase A2
# binds phosphatidylcholine, phosphatidylinositol,
# Binds to fibronectin: The uteroglobulin knockout mice develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. However contrary to the animal model claims, human genetic data might suggest that the effect may be indirectcite journal | author = Vollmer M, Krapf R, Hildebrandt F | title = Exclusion of the uteroglobin gene as a candidate for fibronectin glomerulopathy (GFND) | journal = Nephrol. Dial. Transplant. | volume = 13 | issue = 9 | pages = 2417–8 | year = 1998 | pmid = 9761542 | doi = 10.1093/ndt/13.9.2417 | issn = ]
# Target of Polychlorinated biphenyl (pcb) binding

External links

* [http://marvester.embl.de/marvester/Q063/Q06318.htm Bioinformatic_Harvester]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wolf M, Klug J, Hackenberg R, "et al." |title=Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. |journal=Hum. Mol. Genet. |volume=1 |issue= 6 |pages= 371–8 |year= 1993 |pmid= 1284526 |doi=
*cite journal | author=Bernard A, Roels H, Lauwerys R, "et al." |title=Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. |journal=Clin. Chim. Acta |volume=207 |issue= 3 |pages= 239–49 |year= 1992 |pmid= 1395029 |doi=
*cite journal | author=Singh G, Katyal SL, Brown WE, "et al." |title=Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein. |journal=Biochim. Biophys. Acta |volume=950 |issue= 3 |pages= 329–37 |year= 1988 |pmid= 3167058 |doi=
*cite journal | author=Singh G, Singh J, Katyal SL, "et al." |title=Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein. |journal=J. Histochem. Cytochem. |volume=36 |issue= 1 |pages= 73–80 |year= 1988 |pmid= 3275712 |doi=
*cite journal | author=Jensen SM, Jones JE, Pass H, "et al." |title=Clara cell 10 kDa protein mRNA in normal and atypical regions of human respiratory epithelium. |journal=Int. J. Cancer |volume=58 |issue= 5 |pages= 629–37 |year= 1994 |pmid= 7521325 |doi=
*cite journal | author=Umland TC, Swaminathan S, Singh G, "et al." |title=Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution. |journal=Nat. Struct. Biol. |volume=1 |issue= 8 |pages= 538–45 |year= 1995 |pmid= 7664082 |doi=
*cite journal | author=Hay JG, Danel C, Chu CS, Crystal RG |title=Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. |journal=Am. J. Physiol. |volume=268 |issue= 4 Pt 1 |pages= L565–75 |year= 1995 |pmid= 7733299 |doi=
*cite journal | author=Zhang Z, Zimonjic DB, Popescu NC, "et al." |title=Human uteroglobin gene: structure, subchromosomal localization, and polymorphism. |journal=DNA Cell Biol. |volume=16 |issue= 1 |pages= 73–83 |year= 1997 |pmid= 9022046 |doi=
*cite journal | author=Laing IA, Goldblatt J, Eber E, "et al." |title=A polymorphism of the CC16 gene is associated with an increased risk of asthma. |journal=J. Med. Genet. |volume=35 |issue= 6 |pages= 463–7 |year= 1998 |pmid= 9643286 |doi=
*cite journal | author=Zheng F, Kundu GC, Zhang Z, "et al." |title=Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. |journal=Nat. Med. |volume=5 |issue= 9 |pages= 1018–25 |year= 1999 |pmid= 10470078 |doi= 10.1038/12458
*cite journal | author=Müller-Schöttle F, Classen-Linke I, Alfer J, "et al." |title=Expression of uteroglobin in the human endometrium. |journal=Mol. Hum. Reprod. |volume=5 |issue= 12 |pages= 1155–61 |year= 2000 |pmid= 10587371 |doi=
*cite journal | author=Kundu GC, Zhang Z, Mantile-Selvaggi G, "et al." |title=Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells. |journal=Ann. N. Y. Acad. Sci. |volume=923 |issue= |pages= 234–48 |year= 2001 |pmid= 11193760 |doi=
*cite journal | author=Burmeister R, Boe IM, Nykjaer A, "et al." |title=A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13295–301 |year= 2001 |pmid= 11278724 |doi= 10.1074/jbc.M010679200
*cite journal | author=Matsunaga A, Numakura C, Kawakami T, "et al." |title=Association of the uteroglobin gene polymorphism with IgA nephropathy. |journal=Am. J. Kidney Dis. |volume=39 |issue= 1 |pages= 36–41 |year= 2002 |pmid= 11774099 |doi=
*cite journal | author=Ghafouri B, Ståhlbom B, Tagesson C, Lindahl M |title=Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. |journal=Proteomics |volume=2 |issue= 1 |pages= 112–20 |year= 2002 |pmid= 11788998 |doi=
*cite journal | author=Narita I, Saito N, Goto S, "et al." |title=Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. |journal=Kidney Int. |volume=61 |issue= 5 |pages= 1853–8 |year= 2002 |pmid= 11967037 |doi= 10.1046/j.1523-1755.2002.00336.x
*cite journal | author=Shijubo N, Itoh Y, Abe S |title= [Anti-inflammatory molecule, Clara cell 10 kilodalton protein and respiratory diseases] |journal=Rinsho Byori |volume=50 |issue= 4 |pages= 370–3 |year= 2002 |pmid= 12014016 |doi=
*cite journal | author=Chowdhury B, Mantile-Selvaggi G, Miele L, "et al." |title=Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 877–83 |year= 2002 |pmid= 12127976 |doi=
*cite journal | author=Coppo R, Chiesa M, Cirina P, "et al." |title=In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice. |journal=Am. J. Kidney Dis. |volume=40 |issue= 3 |pages= 495–503 |year= 2002 |pmid= 12200800 |doi=
*cite journal | author=Navab R, Wang Y, Chow YH, "et al." |title=Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs). |journal=Am. J. Respir. Cell Mol. Biol. |volume=27 |issue= 3 |pages= 273–85 |year= 2002 |pmid= 12204889 |doi=

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