Khellin

Khellin
Khellin
Identifiers
CAS number 82-02-0 YesY
PubChem 3828
ChEMBL CHEMBL44746 N
Jmol-3D images Image 1
Properties
Molecular formula C14H12O5
Molar mass 260.24 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Khellin is a furanochromone, an organic compound which is derivative of chromone (1,4-benzopyrone) and furan. It has lipophilic properties and causes vasodilation (widening of blood vessels). It is found in the plant Ammi visnaga which has been used in Egyptian folk medicine.

In Egypt, the plant "Khella" was used for renal colic. The incidence of renal colic was due mostly to schistosomiasis infections and stone formation. The plant mixture had diuretic properties that were seen to relieve renal colic in Egyptian folk medicine. After the chemical compound khellin was identified, people began to study its properties. It was found to relax the ureter and coronary arteries.

It is not used as a systemic medication because it is difficult to absorb and causes a range of undesirable side effects such as dizziness, headache, gastrointestinal disorders and nausea. However, it has been used successfully to treat vitiligo by topical application.[citation needed] In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. A number of drugs were discovered through this research and amiodarone and cromolyn sodium are khellin analogs used in current medical practice.

See also

References

External links


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Look at other dictionaries:

  • Khellin — Khel|lin [arab. khella = nlat. Ammi visnaga = Zahnstocherdolde (Bot.); ↑ in (3)], das; s: ein aus den sog. Ammeifrüchten isolierbares Furochromon Derivat mit spasmolytischer Wirkung. * * * Khellin   das, s, krampflösend wirkender Inhaltsstoff aus …   Universal-Lexikon

  • khellin — noun A derivative of chromone and furan with lipophilic and vasodilatory properties, found in the plant Ammi visnaga …   Wiktionary

  • khellin — The active principle in extracts of Ammi visnaga, an umbelliferous plant growing in the Near East; used in angina pectoris and asthma. [Ar. khella] * * * khel·lin also kel·lin kel ən n a crystalline compound C14H12O5 obtained from the fruit of a… …   Medical dictionary

  • khellin — khel·lin …   English syllables

  • khellin — …   Useful english dictionary

  • Khellinin — Strukturformel Allgemeines Name Khellinin Andere Namen Kh …   Deutsch Wikipedia

  • Roger Altounyan — Roger Edward Collingwood Altounyan (1922­ 1987) was a Syrian born physician and pharmacologist of Armenian and English descent who pioneered the use of sodium cromoglycate as a remedy for asthma. Starting with khellin, a traditional Middle… …   Wikipedia

  • kellin — variant of khellin * * * kellin obs. var. khellin …   Useful english dictionary

  • Cromoglicic acid — Systematic (IUPAC) name 5,5′ (2 hydroxypropane 1,3 diyl)bis(oxy)bis(4 oxo 4H chromene 2 carboxylic acid) Clinical data AHFS/ …   Wikipedia

  • Isidoor Leusen — is a Belgian physiologist was awarded the Francqui Prize on Biological and Medical Sciences in 1969 [Leusen, Isidoor R., Essex, Hiram E., Effects of Epinephrine, Nor Epinephrine and Khellin on Circulation Through Isolated Perfused Hearts, Am J… …   Wikipedia

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