Amikhelline

drugbox
IUPAC_name = 9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyrano [3,2-f] [1] benzoxol-5-one


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CAS_number = 4439-67-2
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PubChem = 71198
DrugBank =
C=18 | H=21 | N=1 | O=5
molecular_weight = 331.363 g/mol
bioavailability =
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metabolism = none
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Amikhelline is an antimitotic drug. [Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). "Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales". 1985;179(3):331-9. PMID 2417673] It acts as a DNA intercalator [Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. "Biochimie". 1973;55(11):1415-20. PMID 4364376] and inhibits DNA polymerase. [Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. "Biochimie". 1976;58(6):689-95. PMID 60141]

References