G-protein coupled receptor kinases
- G-protein coupled receptor kinases
G-Protein coupled receptor kinases (GRKs), regulate the activity of G-protein coupled receptors by phosphorylating their intracellular domains after their associated G-proteins have been released and activated.
The phosphorylated serines and threonine residues act as binding sites for arrestin proteins which prevent the reassociation of the G-proteins with their receptors, thereby preventing reactivation of the signaling pathway.
Types
External links
*Enzyme classification: EC number|2.7.11.16
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