Fucosyltransferase

Fucosyltransferase

A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose (Guanosine diphosphate-fucose) donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of "O"-linked glycosylation produced by "O"-fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The "O"-fucosyltransferases have recently been shown to localize to the ER.

Fucosyltransferase activity may be a risk factor for urinary tract infection.

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  • fucosyltransferase — noun A transferase that catalyzes the transfer of fucose sugars …   Wiktionary

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