GDP-fucose protein O-fucosyltransferase 2
- GDP-fucose protein O-fucosyltransferase 2
protein
Name=protein O-fucosyltransferase 2
caption=
width=
HGNCid=14683
Symbol=POFUT2
AltSymbols=C21orf80
EntrezGene=23275
OMIM=610249
RefSeq=NM_133634
UniProt=Q9Y2G5
PDB=
ECnumber=
Chromosome=21
Arm=q
Band=22.3
LocusSupplementaryData=
GDP-fucose protein "O"-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in "O" linkage to serine or threonine residues in Thrombospondin repeats. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in "O" linkage to the protein producing fucose-α-"O"-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
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