Glycoprotein 3-alpha-L-fucosyltransferase

In enzymology, a glycoprotein 3-alpha-L-fucosyltransferase (EC number|2.4.1.214) is an enzyme that catalyzes the chemical reaction

:GDP-L-fucose + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine $ightleftharpoons$ GDP + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)- [alpha-L- fucosyl-(1->3)] -N-acetyl-beta-D-glucosaminyl}asparagine

The 5 substrates of this enzyme are GDP-L-fucose, [N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-] , acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine, whereas its 5 products are GDP, [N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-] , acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, [mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)- [alpha-L-] , and fucosyl-(1->3)] -N-acetyl-beta-D-glucosaminyl}asparagine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 3-alpha-L-fucosyl-transferase. Other names in common use include GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase, GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase, GDP-fucose:beta-N-acetylglucosamine (Fuc to, (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase, GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked, N-acetylglucosamine of, 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-, acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase. This enzyme participates in glycan structures - biosynthesis 1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|68247-53-0."

Gene Ontology (GO) codes