GCNT1

Glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase), also known as GCNT1, is a human gene.cite web | title = Entrez Gene: GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2650| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.cite web | title = Entrez Gene: GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2650| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bierhuizen MF, Fukuda M |title=Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9326–330 |year= 1992 |pmid= 1329093 |doi=
*cite journal | author=Bierhuizen MF, Maemura K, Kudo S, Fukuda M |title=Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family. |journal=Glycobiology |volume=5 |issue= 4 |pages= 417–25 |year= 1995 |pmid= 7579796 |doi=
*cite journal | author=Bierhuizen MF, Mattei MG, Fukuda M |title=Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. |journal=Genes Dev. |volume=7 |issue= 3 |pages= 468–78 |year= 1993 |pmid= 8449405 |doi=
*cite journal | author=Skrincosky D, Kain R, El-Battari A, "et al." |title=Altered Golgi localization of core 2 beta-1,6-N-acetylglucosaminyltransferase leads to decreased synthesis of branched O-glycans. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22695–702 |year= 1997 |pmid= 9278427 |doi=
*cite journal | author=Yeh JC, Ong E, Fukuda M |title=Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 3215–21 |year= 1999 |pmid= 9915862 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Beum PV, Bastola DR, Cheng PW |title=Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line. |journal=Am. J. Respir. Cell Mol. Biol. |volume=29 |issue= 1 |pages= 48–56 |year= 2003 |pmid= 12600830 |doi= 10.1165/rcmb.2002-0147OC
*cite journal | author=Falkenberg VR, Alvarez K, Roman C, Fregien N |title=Multiple transcription initiation and alternative splicing in the 5' untranslated region of the core 2 beta1-6 N-acetylglucosaminyltransferase I gene. |journal=Glycobiology |volume=13 |issue= 6 |pages= 411–8 |year= 2004 |pmid= 12626388 |doi= 10.1093/glycob/cwg039
*cite journal | author=Chibber R, Ben-Mahmud BM, Mann GE, "et al." |title=Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy. |journal=Diabetes |volume=52 |issue= 6 |pages= 1519–27 |year= 2003 |pmid= 12765965 |doi=
*cite journal | author=Smith MJ, Smith BR, Lawrence MB, Snapp KR |title=Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 21984–91 |year= 2004 |pmid= 15026421 |doi= 10.1074/jbc.M402731200
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Kikuchi J, Shinohara H, Nonomura C, "et al." |title=Not core 2 beta 1,6-N-acetylglucosaminyltransferase-2 or -3 but -1 regulates sialyl-Lewis x expression in human precursor B cells. |journal=Glycobiology |volume=15 |issue= 3 |pages= 271–80 |year= 2005 |pmid= 15483269 |doi= 10.1093/glycob/cwi005
*cite journal | author=Beum PV, Basma H, Bastola DR, Cheng PW |title=Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=288 |issue= 1 |pages= L116–24 |year= 2005 |pmid= 15591039 |doi= 10.1152/ajplung.00370.2003
*cite journal | author=Wang L, Mitoma J, Tsuchiya N, "et al." |title=An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 4 |pages= 958–63 |year= 2005 |pmid= 15882971 |doi= 10.1016/j.bbrc.2005.04.022
*cite journal | author=Prorok-Hamon M, Notel F, Mathieu S, "et al." |title=N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding. |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 491–502 |year= 2006 |pmid= 15926890 |doi= 10.1042/BJ20050344
*cite journal | author=Hagisawa S, Ohyama C, Takahashi T, "et al." |title=Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression. |journal=Glycobiology |volume=15 |issue= 10 |pages= 1016–24 |year= 2006 |pmid= 15932919 |doi= 10.1093/glycob/cwi086
*cite journal | author=Kikuchi J, Ozaki H, Nonomura C, "et al." |title=Transfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells. |journal=Leukemia |volume=19 |issue= 11 |pages= 1934–40 |year= 2005 |pmid= 16179912 |doi= 10.1038/sj.leu.2403951
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Cabrera PV, Amano M, Mitoma J, "et al." |title=Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death. |journal=Blood |volume=108 |issue= 7 |pages= 2399–406 |year= 2006 |pmid= 16778138 |doi= 10.1182/blood-2006-04-018556
*cite journal | author=Julien S, Grimshaw MJ, Sutton-Smith M, "et al." |title=Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I. |journal=J. Immunol. |volume=179 |issue= 9 |pages= 5701–10 |year= 2007 |pmid= 17947642 |doi=

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