Glycoprotein 6-alpha-L-fucosyltransferase

In enzymology, a glycoprotein 6-alpha-L-fucosyltransferase (EC number|2.4.1.68) is an enzyme that catalyzes the chemical reaction

:GDP-L-fucose + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine $ightleftharpoons$ GDP + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)- [alpha-L- fucosyl-(1->6)] -N-acetyl-beta-D-glucosaminyl}asparagine

The 5 substrates of this enzyme are GDP-L-fucose, [N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-] , acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine, whereas its 5 products are GDP, [N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-] , acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, [mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)- [alpha-L-] , and fucosyl-(1->6)] -N-acetyl-beta-D-glucosaminyl}asparagine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 6-alpha-L-fucosyltransferase. Other names in common use include GDP-fucose-glycoprotein fucosyltransferase, GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked, N-acetylglucosamine of, 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-, acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase, and FucT. This enzyme participates in 3 metabolic pathways: n-glycan biosynthesis, keratan sulfate biosynthesis, and glycan structures - biosynthesis 1.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2DE0, PDB link|2HHC, and PDB link|2HLH.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9033-08-3."

Gene Ontology (GO) codes