4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (EC number|2.4.1.152) is an enzyme that catalyzes the chemical reaction

:GDP-beta-L-fucose + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R $ightleftharpoons$ GDP + 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl- R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, whereas its 3 products are GDP, 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-, and R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase. Other names in common use include Lewis-negative alpha-3-fucosyltransferase, plasma alpha-3-fucosyltransferase, guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase, galactoside 3-fucosyltransferase, GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, 3-L-fucosyltransferase, GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and 3-L-fucosyltransferase. This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2NZW, PDB link|2NZX, and PDB link|2NZY.

References

*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|111310-38-4."

Gene Ontology (GO) codes