- Influenza A virus subtype H1N2
H1N1, H1N2, and H3N2are the only known Influenza A virus subtypes currently circulating among humans.
The new A(H1N2) strain appears to have resulted from the
reassortmentof the genes of the currently circulating influenza A( H1N1) and A( H3N2) subtypes. The hemagglutinin proteinof the A(H1N2) virus is similar to that of the currently circulating A(H1N1) viruses and the neuraminidase proteinis similar to that of the current A(H3N2) viruses.
It is unknown where the A(H1N2) virus originated, but on
February 6 2002, the World Health Organization(WHO) in Genevaand the Public Health Laboratory Service(PHLS) in the United Kingdomreported the identification influenza A(H1N2) virus from humans in England, Israel, and Egypt. In addition to the virus isolates reported by WHO and PHLS, the Centers for Disease Control and Preventionhas identified influenza A(H1N2) virus from patient specimens collected during the 2001- 2002and 2002- 2003seasons.* Influenza A(H1N2) viruses have circulated transiently in the past. Between December 1988and March 1989, 19 influenza A(H1N2) virus isolates were identified in 6 cities in China, but the virus did not spread further.
A(H1N2) was also identified during the
2001- 2002flu season (northern hemisphere) in Canada, the U.S.A., Ireland, Latvia, France, Romania, Oman, India, Malaysia, and Singapore. [ [http://www.datasync.com/~rsf1/vel/1918h1n2.htm Influenza A(H1N2)] - Shade Tree Physics]
The H1N2 virus is not very different from the currently circulating influenza viruses. The H1 protein of the H1N2 virus is like the H1 protein of the currently circulating H1N1 viruses and the N2 protein is similar to the N2 protein in the currently circulating H3N2 viruses. The difference is that we don't commonly see the H1 and N2 proteins on the same virus.
The A(H1N2) virus is not causing a more severe illness than other influenza viruses, and no unusual increases in influenza activity have been associated with the A(H1N2) virus. Because both the hemagglutinin and neuraminidase protein on the A(H1N2) virus closely matches the hemagglutinin and neuraminidase proteins of viruses included in the current
influenza vaccine, the vaccine should provide good protection against influenza A(H1N2) virus as well as protection against the currently circulating A(H1N1), A(H3N2), and B viruses.
* [http://www.cdc.gov/flu/about/h1n2qa.htm Questions and Answers About Influenza A(H1N2) Viruses] This is the source of most of this article.
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12191781&dopt=Citation Phylogenetic analysis of H1N2 isolates of influenza A virus from pigs in the United States]
* [http://www.cdc.gov/flu/avian/gen-info/facts.htm CDC]
Wikimedia Foundation. 2010.