Oxalate—CoA ligase

Oxalate—CoA ligase
oxalate-CoA ligase
Identifiers
EC number 6.2.1.8
CAS number 37318-57-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an oxalate-CoA ligase (EC 6.2.1.8) is an enzyme that catalyzes the chemical reaction

ATP + oxalate + CoA \rightleftharpoons AMP + diphosphate + oxalyl-CoA

The 3 substrates of this enzyme are ATP, oxalate, and CoA, whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase (AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

  • Giovanelli J (1966). "Oxalyl-coenzyme A synthetase from pea seeds". Biochim. Biophys. Acta. 118 (1): 124–43. PMID 4288975. 
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