- Organic anion-transporting polypeptide
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Organic Anion Transporter Polypeptide (OATP) family Identifiers Symbol OATP Pfam PF03137 InterPro IPR004156 TCDB 2.A.60 Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary An organic anion-transporting polypeptide (OATP) is a membrane transport protein that mediates the transport of organic anions across the cell membrane. Organic anion-transporting proteins belong to the solute carrier family, more specific, subfamily 21 (organic anion transporting).[1]
Contents
Function
Organic anion transporters may carry bile acids as well as bilirubin over the basolateral membrane (facing sinusoids) in hepatocytes, as well as other anions for excretion in bile. [2]
They also transport the dye bromsulphthalein, availing it as a liver-testing substance. [2]
Other OAT proteins transport organic anions across the basolateral side of renal proximal tubule cells during renal secretion.
Proteins
These organic anion transporting proteins have been found in human cells.
Abbreviation Protein Name Location SLCO1A2 Solute carrier organic anion transporter family member 1A2 Liver SLCO1B1 Solute carrier organic anion transporter family member 1B1 Liver SLCO1B3 Solute carrier organic anion transporter family member 1B3 Liver SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Many SLCO3A1 Solute carrier organic anion transporter family member 3A1 SLCO4A1 Solute carrier organic anion transporter family member 4A1 SLCO4C1 Kidneys SLCO5A1 SLCO6A1 Organic anion transporter (OAT) family
The SLC22A gene family codes for organic anion transporter (OAT) proteins. The OAT family plays the central role in renal organic anion transport. OAT1, OAT3, OAT4, and URAT1 are expressed in the proximal tubular cells of the kidneys. OAT1 and OAT3 mediate uptake of a wide range of relatively small and hydrophilic organic anions from plasma. URAT1 transports those organic anions from the cytoplasm of the proximal tubular cells into the lumen of the nephron. [3] Organic anion transporters are within the organic cation transport proteins family.
Abbreviation Gene Protein Name Location OAT1 SLC22A6 Solute carrier family 22 member 6 Brain, placenta, eyes, smooth muscle,
and the basolateral membrane of renal proximal tubule cellsOAT2 SLC22A7 Solute carrier family 22 member 7 Liver, and kidneys OAT3 SLC22A8 Solute carrier family 22 member 8 Bone, brain, eyes, liver, adrenal glands,
and the basolateral membrane of renal proximal tubule cellsOAT4 SLC22A11 Solute carrier family 22 member 11 Placenta, and the apical membrane of the renal proximal tubule cells OAT5 SLC22A10 Solute carrier family 22 member 10 Kidneys URAT1 SLC22A12 Solute carrier family 22 member 12 Brain, vascular smooth muscle cells,
and the apical membrane of the renal proximal tubule cellsPharmacology
Probenecid inhibits organic anion transporters. [4]
References
- ^ Hagenbuch B, Meier PJ (2004). "Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties". Pflugers Arch 447 (5): 653–665. doi:10.1007/s00424-003-1168-y. PMID 14579113.
- ^ a b Pages 980-990 in:Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. pp. 1300. ISBN 1-4160-2328-3.
- ^ Takashi Sekine et al. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol 290: F251-F261, 2006
- ^ Karen L. Price et al. Human Vascular Smooth Muscle Cells Express a Urate Transporter. J Am Soc Nephrol 17: 1791-1795, 2006
Categories:- Solute carrier family
- Transmembrane proteins
- Transmembrane transporters
- Transport proteins
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