OATP4C1

OATP4C1

Organic anion transporter polypeptide 4C1 or OATP4C1 is a human protein. It is also known as "solute carrier organic anion transporter family member 4A1". OATP4C1 is coded for by the gene SLCO4C1, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.[1]

References

  1. ^ Mikkaichi T, Suzuki T, Onogawa T, et al. (March 2004). "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3569–74. doi:10.1073/pnas.0304987101. PMC 373503. PMID 14993604. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=14993604. 

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  • Organic anion transporter 1 — Figure 1 Schematic representation of transmembrane proteins: 1. a membrane protein with one transmembrane domain 2. a membrane protein with three transmembrane domains 3. OAT1 is believed to have twelve transmembrane domains. [1] The membrane is… …   Wikipedia

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