Piecemeal necrosis

Sclerotic piecemeal necrosis of the tip of the thumb in a patient with scleroderma.

Piecemeal necrosis generally refers to a necrosis that occurs in fragments.

Liver

When used in relation to the liver, piecemeal necrosis (also termed troxis necrosis,^[1] nibbling necrosis^[1] and interface necrosis^[1]) refers specifically to a loss and degeneration of hepatocytes at the lobular-portal-interface, producing a moth-eaten irregular appearance.^[2] Piecemeal necrosis of the liver is associated with a lymphocytic infiltrate^[2] into the adjacent parenchyma,^[3] and with destruction of individual hepatocytes along the edges of the portal tract.^[3]

It is a feature of viral hepatitis as well as autoimmune hepatitis and steatohepatitis.^[1]

References

1. ^ ^{a b c d} Wang, M.; Morgan, T.; Lungo, W.; Wang, L.; Sze, G. Z.; French, S. W. (2001). ""Piecemeal" Necrosis: Renamed Troxis Necrosis". Experimental and Molecular Pathology 71 (2): 137–146. doi:10.1006/exmp.2001.2397. PMID 11599920.  edit
2. ^ ^{a b} Pathbase > MPATH 597: cell and tissue damage process > MPATH 13: piecemeal necrosis Retrieved July 2, 2011
3. ^ ^{a b} Transplant Pathology at the University of Pittsburgh > Chronic hepatitis > Chapter 3 > PATHOLOGIC FEATURES Last Modified: Mar 12, 2010

This article related to pathology is a stub. You can help Wikipedia by expanding it.v · Categories: Pathology stubs Hepatology Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Galaxy National Book Awards Flavor of Love (season 2) Look at other dictionaries: piecemeal necrosis — interface hepatitis …   Medical dictionary hepatitis — Inflammation of the liver, due usually to viral infection but sometimes to toxic agents. [hepat + itis] Previously endemic throughout much of the developing world, viral h. now ranks as a major public health problem in industrialized nations. The …   Medical dictionary Wilson's disease — Classification and external resources A Kayser Fleischer ring (the brown ring on the edge of the iris) is common in Wilson s disease, especially when neurological symptoms are present ICD …   Wikipedia chronic active hepatitis — chronic aggressive hepatitis chronic inflammation of the liver occurring as a sequel to hepatitis B or certain other types of hepatitis, in congenital or acquired hypogammaglobulinemia, or following administration of certain drugs; in some cases… …   Medical dictionary interface hepatitis — destruction of liver cells at the interface between liver parenchyma and portal triads, usually associated with lymphocytic infiltration; it is characteristic of severe chronic active hepatitis and primary biliary cirrhosis. Called also piecemeal …   Medical dictionary Caries — Ca ri*es, n. [L., decay.] (Med.) Ulceration of bone; a process in which bone disintegrates and is carried away piecemeal, as distinguished from necrosis, in which it dies in masses. [1913 Webster] …   The Collaborative International Dictionary of English Naegleria fowleri — Different stages of Naegleria fowleri Scientific classification Domain: Eukaryota Phylum …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”