Testosterone undecanoate

Testosterone undecanoate

Systematic (IUPAC) name
[(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] undecanoate
Clinical data
Pregnancy cat.	X (USA), Teratogenic effects
Legal status	Schedule III (USA) Schedule IV (Canada)
Routes	oral,I.V
Pharmacokinetic data
Bioavailability	7%
Metabolism	Liver, Testis and Prostate
Half-life	1-12 days
Excretion	Urine
Identifiers
CAS number	5949-44-0
ATC code	G03BA03
PubChem	CID 65157
ChemSpider	23089522 Y
KEGG	D06087 Y
Chemical data
Formula	C30H48O3
Mol. mass	456.70032
InChI InChI=1S/C29H46O3/c1-4-5-6-7-8-9-10-11-27(31)32-26-15-14-24-23-13-12-21-20-22(30)16-18-28(21,2)25(23)17-19-29(24,26)3/h20,23-26H,4-19H2,1-3H3/t23?,24?,25?,26-,28-,29-/m0/s1 Y Key:LBERVHLCXUMDOT-SSRQPSIZSA-N Y
Y(what is this?)  (verify)

Testosterone undecanoate or testosterone undecylate is an ester of testosterone which is used for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive. It is sold and distributed under the brand names Andriol, Undestor, Nebido, Pantestone, Restandol, Cernos Depot and Nebido-R and Reandron 1000.^[1]

Andriol is a version of the anabolic steroid testosterone undecanoate developed by the pharmaceutical company Organon. This testosterone preparation is encapsulated and sealed in an oil base in a 40 mg capsule taken orally. According to Organon, this method bypasses the liver, preventing it from being damaged by the liver and from adding damaging stresses to the liver found in other testosterone preparations. It is said to enter the body as a fat through the lymphatic system. Experience from users indicates that in doses of less than 240 mg per day, effects are negligible, except at the very onset of use, while even in higher doses, effects are still minimal. It is therefore thought that most of the steroid is somehow not making it into the blood stream.^[2]

References

1. ^ Köhn, FM; Schill, WB (Nov 2003). "A new oral testosterone undecanoate formulation.". World J Urol 21 (5): 311–5. doi:10.1007/s00345-003-0372-x. PMID 14579074. 
2. ^ http://www.mesomorphosis.com/steroid-profiles/andriol.htm, http://www.steroidology.com/andriol-testosterone-undecanoate/, http://www.testosteroneundecanoate.com/, http://www.medicinenet.com/testosterone_undecanoate-oral_capsule/article.htm

External links

• MeSH testosterone+undecanoate

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.v · Categories: Anabolic steroids Androgens Contraception for males Testosterone Genito-urinary system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Nebi Sefa Nebiha Gueddana Look at other dictionaries: Testosterone — For the film, see Testosterone (film). Testosterone Systematic (IUPAC) name …   Wikipedia Male contraceptive — Male contraceptives include condoms, withdrawal (although medical professionals do not regard this as an effective method of contraception), and vasectomy.[1] In other animals, castration is commonly used for contraception. Other forms of male… …   Wikipedia Hormone replacement therapy (female-to-male) — Hormone replacement therapy (HRT) for transgender and transsexual people replaces the hormones naturally occurring in their bodies with those of the other sex. However, not all cases of hormone replacement therapy are used by transgendered people …   Wikipedia Anabolic steroid — cite journal author=Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA title=Crystal structure of human sex hormone binding globulin: steroid transport by a laminin G like domain journal=EMBO J. volume=19 issue=4… …   Wikipedia Anabolisant — Stéroïde anabolisant Structure de la sex hormone binding globulin, transportant la 5α dihydrotestosterone.[1] Les stéroïdes anabolisants, également connus sous le nom de stéroïdes …   Wikipédia en Français Steroide anabolisant — Stéroïde anabolisant Structure de la sex hormone binding globulin, transportant la 5α dihydrotestosterone.[1] Les stéroïdes anabolisants, également connus sous le nom de stéroïdes …   Wikipédia en Français Stéroide anabolisant — Stéroïde anabolisant Structure de la sex hormone binding globulin, transportant la 5α dihydrotestosterone.[1] Les stéroïdes anabolisants, également connus sous le nom de stéroïdes …   Wikipédia en Français Stéroïde anabolisant — Les stéroïdes anabolisants, également connus sous le nom de stéroïdes androgéniques anabolisants ou SAA, sont une classe d hormone stéroïdiennes liée à une hormone naturelle humaine : la testostérone. Ils augmentent la synthèse des protéines …   Wikipédia en Français Stéroïdes anabolisants — Stéroïde anabolisant Structure de la sex hormone binding globulin, transportant la 5α dihydrotestosterone.[1] Les stéroïdes anabolisants, également connus sous le nom de stéroïdes …   Wikipédia en Français Testosterona — Para otros usos de este término, véase Testosterona (desambiguación). Testosterona …   Wikipedia Español 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”