- NOM1
-
Nucleolar protein with MIF4G domain 1 Identifiers Symbols NOM1; C7orf3; FLJ16401; SGD1 External IDs OMIM: 611269 HomoloGene: 39776 GeneCards: NOM1 Gene Gene Ontology Molecular function • protein binding Cellular component • nucleus
• nucleolusBiological process • biological_process
• RNA metabolic processSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 64434 433864 Ensembl ENSG00000146909 ENSMUSG00000001569 UniProt Q5C9Z4 E9QPB9 RefSeq (mRNA) NM_138400.1 NM_001033457.2 RefSeq (protein) NP_612409.1 NP_001028629.2 Location (UCSC) Chr 7:
156.74 – 156.77 MbChr 5:
29.76 – 29.78 MbPubMed search [1] [2] This box: view · protein that in humans is encoded by the NOM1 gene.[1] Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM].[1]
References
Further reading
- Heus, H. C.; Hing, A.; Van Baren, M. J.; Joosse, M.; Breedveld, G. J.; Wang, J. C.; Burgess, A.; Donnis-Keller, H. et al. (1999). "A Physical and Transcriptional Map of the Preaxial Polydactyly Locus on Chromosome 7q36". Genomics 57 (3): 342–351. doi:10.1006/geno.1999.5796. PMID 10329000. edit
- Simmons, H. M.; Ruis, B. L.; Kapoor, M.; Hudacek, A. W.; Conklin, K. F. (2005). "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia". Gene 347 (1): 137–145. doi:10.1016/j.gene.2004.12.027. PMID 15715967. edit
- Gunawardena, S. R.; Ruis, B. L.; Meyer, J. A.; Kapoor, M.; Conklin, K. F. (2007). "NOM1 Targets Protein Phosphatase I to the Nucleolus". Journal of Biological Chemistry 283 (1): 398–404. doi:10.1074/jbc.M706708200. PMID 17965019. edit
- Alexandrov, A.; Colognori, D.; Steitz, J. A. (2011). "Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex". Genes & Development 25 (10): 1078–1090. doi:10.1101/gad.2045411. PMC 3093123. PMID 21576267. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3093123. edit
Categories:- Human proteins
- Chromosome 7 gene stubs
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NOM1
- NOM1
-
Nucleolar protein with MIF4G domain 1 Identifiers Symbols NOM1; C7orf3; FLJ16401; SGD1 External IDs OMIM: 611269 HomoloGene: 39776 GeneCards: NOM1 Gene Gene Ontology Molecular function • protein binding Cellular component • nucleus
• nucleolusBiological process • biological_process
• RNA metabolic processSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 64434 433864 Ensembl ENSG00000146909 ENSMUSG00000001569 UniProt Q5C9Z4 E9QPB9 RefSeq (mRNA) NM_138400.1 NM_001033457.2 RefSeq (protein) NP_612409.1 NP_001028629.2 Location (UCSC) Chr 7:
156.74 – 156.77 MbChr 5:
29.76 – 29.78 MbPubMed search [1] [2]