MUSCLE (alignment software)

For the toy, see M.U.S.C.L.E..

MUSCLE (multiple sequence comparison by log-expectation) is public domain, multiple sequence alignment software for protein and nucleotide sequences.^[1][2]

MUSCLE is often used as a replacement for Clustal, since it typically (but not always) gives better sequence alignments; in addition, MUSCLE is significantly faster than Clustal, especially for larger alignments (Edgar 2004).

MUSCLE is integrated into UGENE bioinformatics tool as a plugin.

See also

• Sequence alignment software
• Clustal
• ProbCons
• AMAP
• T-COFFEE
• MAFFT
• Geneious Pro includes MUSCLE as part of its all-in-one sequence analysis platform.

References

1. ^ Edgar RC (2004). "MUSCLE: multiple sequence alignment with high accuracy and high throughput". Nucleic Acids Research 32 (5): 1792–97. doi:10.1093/nar/gkh340. PMC 390337. PMID 15034147. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=390337. 
2. ^ Edgar RC (2004). "MUSCLE: a multiple sequence alignment method with reduced time and space complexity". BMC Bioinformatics 5 (1): 113. doi:10.1186/1471-2105-5-113. PMC 517706. PMID 15318951. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=517706. 

External links

• Official website
• MUSCLE Web Server

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