Mitochondrial ribosomal protein L41

Mitochondrial ribosomal protein L41
Identifiers
Symbols	MRPL41; BMRP; MRP-L27; MRPL27; RPML27
External IDs	OMIM: 611846 MGI: 1333816 HomoloGene: 13036 GeneCards: MRPL41 Gene
Gene Ontology Molecular function • structural constituent of ribosome Cellular component • mitochondrion • mitochondrial large ribosomal subunit • ribosome • ribonucleoprotein complex Biological process • translation • apoptosis • cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64975	107733
Ensembl	ENSG00000182154	ENSMUSG00000036850
UniProt	Q8IXM3	n/a
RefSeq (mRNA)	NM_032477	NM_001031808.2
RefSeq (protein)	NP_115866	NP_001026978.2
Location (UCSC)	Chr 9: 140.45 – 140.45 Mb	Chr 2: 24.83 – 24.83 Mb
PubMed search	[1]	[2]

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.^[1][2]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.^[2]

References

1. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634. 
2. ^ ^{a b} "Entrez Gene: MRPL41 mitochondrial ribosomal protein L41". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64975. 

Further reading

• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009. 
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105. 
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Chintharlapalli SR, Jasti M, Malladi S, et al. (2005). "BMRP is a Bcl-2 binding protein that induces apoptosis.". J. Cell. Biochem. 94 (3): 611–26. doi:10.1002/jcb.20292. PMID 15547950. 
• Yoo YA, Kim MJ, Park JK, et al. (2005). "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1.". Mol. Cell. Biol. 25 (15): 6603–16. doi:10.1128/MCB.25.15.6603-6616.2005. PMC 1190350. PMID 16024796. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1190350. 
• Kim MJ, Yoo YA, Kim HJ, et al. (2006). "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1).". Biochem. Biophys. Res. Commun. 338 (2): 1179–84. doi:10.1016/j.bbrc.2005.10.064. PMID 16256947.