Mitochondrial ribosomal death-associated protein 3
- Mitochondrial ribosomal death-associated protein 3
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In molecular biology, the mitochondrial ribosomal death-associated protein 3 family of proteins is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis.[1] DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix [2] and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).
References
- ^ Kissil JL, Cohen O, Raveh T, Kimchi A (January 1999). "Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death". EMBO J. 18 (2): 353–62. doi:10.1093/emboj/18.2.353. PMC 1171130. PMID 9889192. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171130.
- ^ Berger T, Brigl M, Herrmann JM, Vielhauer V, Luckow B, Schlondorff D, Kretzler M (October 2000). "The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins". J. Cell. Sci. 113 ( Pt 20): 3603–12. PMID 11017876.
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