Dynamic combinatorial chemistry

Dynamic combinatorial chemistry

Dynamic combinatorial chemistry is defined as combinatorial chemistry under thermodynamic control.[1]



In a dynamic combinatorial library, all constituents are in equilibrium. The interconversion of library members into one another is through a reversible process that can involve covalent or non-covalent interactions. The composition of the library is determined by the thermodynamic stability of each of the library members under the particular conditions of the experiment.[2]

Current Applications

DCC is useful in identifying molecules with unusual binding properties, and provides synthetic routes to complex molecules that aren't easily accessible by other means.

Medicine and Pharmaceuticals

drug delivery, synthetic receptors, biochem ligands, biosensors


smart materials




Self-assembling molecules

interlocking architectures and new soft materials

Virtual Libraries and Molecular Modeling

Prospects and Challenges

See also


  1. ^ P.T. Corbett et al. "Dynamic Combinatorial Chemistry" [Chem. Rev. 106 (2006) 3652]
  2. ^ P.T. Corbett et al. "Dynamic Combinatorial Chemistry" [Chem. Rev. 106 (2006) 3652]

External links

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