Protein dimer

Protein dimer
Cartoon diagram of a dimer of Escherichia coli galactose-1-phosphate uridylyltransferase (GALT) in complex with UDP-galactose (stick models). Potassium, zinc, and iron ions are visible as purple, gray, and bronze-colored spheres respectively.

In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolecules like proteins or nucleic acids. It is a quaternary structure of a protein.

A homo-dimer would be formed by two identical molecules (process called homodimerization). A hetero-dimer would be formed by two different macromolecules (process called heterodimerization).

Most dimers in biochemistry are not connected by covalent bonds with the exception of disulfide bridges. An example of this would be the enzyme reverse transcriptase, which is made of two different amino acid chains.[1]

Some proteins contain specialized domains to ensure dimerization (dimerization domains).

Examples

References

  1. ^ Nicolas Sluis-Cremer, Noureddine Hamamouch, Ana San Félix, Sonsoles Velázquez, Jan Balzarini, and María-José Camarasa (2006). "Structure-Activity Relationships of [2‘,5‘-Bis-O-(tert-butyldimethylsilyl)-ß-d-ribofuranosyl]- 3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide)thymine Derivatives as Inhibitors of HIV-1 Reverse Transcriptase Dimerization". J. Med. Chem. 49 (16): 4834–4841. doi:10.1021/jm0604575. PMID 16884295. 

See also

  • Dimer
  • Protein trimer
  • ProtCID

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Dimer — may refer to: Dimer (chemistry), a chemical structure formed from two sub units Dimer model, an item in statistical mechanics Protein dimer, a protein quaternary structure Julius Dimer (1871–1945), a German chess master Dimerous refer to plants… …   Wikipedia

  • protein — proteinaceous /proh tee nay sheuhs, tee i nay /, proteinic, proteinous, adj. /proh teen, tee in/, n. 1. Biochem. any of numerous, highly varied organic molecules constituting a large portion of the mass of every life form and necessary in the… …   Universalium

  • Protein kinase — A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). This class of protein may further be separated into subsets as in the case of protein kinase C PKC alpha, PKC beta,… …   Wikipedia

  • Protein quaternary structure — In biochemistry, quaternary structure is the arrangement of multiple folded protein or coiling protein molecules in a multi subunit complex. Contents 1 Description and examples 2 Nomenclature of quaternary structures 3 Determination of qua …   Wikipedia

  • Protein structure — Proteins are an important class of biological macromolecules present in all biological organisms, made up of such elements as carbon, hydrogen, nitrogen, phosphorus, oxygen, and sulfur. All proteins are polymers of amino acids. The polymers, also …   Wikipedia

  • dimer — A compound or unit produced by the combination of two like molecules; in the strictest sense, without loss of atoms (thus nitrogen tetroxide, N2O4, is the d. of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small …   Medical dictionary

  • Ribosomal protein S19 — Ribosomal protein S19, also known as RPS19, is a human gene.cite web | title = Entrez Gene: RPS19 ribosomal protein S19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6223| accessdate = ] PBB Summary… …   Wikipedia

  • nuclear actin binding protein — Nuclear protein, dimer of 34 kD subunits. Binds actin with Kd of around 25 m M …   Dictionary of molecular biology

  • Major sperm protein — MSP Structure of MSP dimer from A. suum. The β sheets are shown in orange Identifiers Symbol Major Sperm Protein, MSP Entrez …   Wikipedia

  • D-dimer — is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrinogen protein.[1] D dimer… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”