Digital pathology

Digital Pathology is an image-based information environment enabled by computer technology that allows for the management of information generated from a digital slide. Digital pathology is enabled in part by virtual microscopy, which is the practice of converting glass slides into digital slides that can be viewed, managed, and analyzed.

Digital Pathology Environment

Scan

Digital slides are created from glass slides using a scanning device.

View

Digital slides are accessible for viewing via a computer monitor and viewing software.

Manage

Digital slides are maintained in an information management system that allows for archival and intelligent retrieval.

Analyze

Image analysis tools are used to derive objective quantification measures from digital slides.

Integrate

Digital pathology workflow is integrated into the institution's overall operational environment.

Sharing

Digital pathology also allows internet information sharing for education, diagnostics, publication and research.

See also

• Pathology
• Anatomical Pathology
• Surgical pathology
• Histology
• Cytopathology
• Microscopy
• Virtual microscopy
• Medical laboratory
• Important publications in pathology
• Telepathology

References

Further reading

• Kayser, K; Kayser, G; Radziszowski, D; Oehmann, A (1999). "From telepathology to virtual pathology institution: The new world of digital pathology". Romanian journal of morphology and embryology 45: 3–9. PMID 15847374. http://www.rjme.ro/RJME/resources/files/3_9_KayserK%20telepathology.pdf. 
• McCullough, Bruce; Ying, Xiaoyou; Monticello, Thomas; Bonnefoi, Marc (2004). "Digital Microscopy Imaging and New Approaches in Toxicologic Pathology". Toxicologic Pathology 32 (5): 49–58. doi:10.1080/01926230490451734. 
• Schlangen, David; Stede, Manfred; Bontas, Elena Paslaru (2004). "Feeding OWL: Extracting and Representing the Content of Pathology Reports". NLPXML '04 Proceeedings of the Workshop on NLP and XML. http://dl.acm.org/citation.cfm?id=1621073. 
• "E-Health and Telemedicine". International Journal of Computer Assisted Radiology and Surgery 1 (Supplement 1): 119–35. 2006. doi:10.1007/s11548-006-0012-1. 
• Fine, Jeffrey L.; Grzybicki, Dana M.; Silowash, Russell; Ho, Jonhan; Gilbertson, John R.; Anthony, Leslie; Wilson, Robb; Parwani, Anil V. et al. (2008). "Evaluation of whole slide image immunohistochemistry interpretation in challenging prostate needle biopsies". Human Pathology 39 (4): 564–72. doi:10.1016/j.humpath.2007.08.007. PMID 18234276. 
• Kayser, Klaus; Kayser, Gian; Radziszowski, Dominik; Oehmann, Alexander (2004). "New Developments in Digital Pathology: from Telepathology to Virtual Pathology Laboratory". In Duplaga, Mariusz; Zieliński, Krzysztof; Ingram, David. Transformation of Healthcare with Information Technologies. Studies in Health Technology and Informatics. IOS Press. pp. 61–9. ISBN 978-1-58603-438-2. ISSN 0926-9630. PMID 15718595. http://iospress.metapress.com/content/hgjhbq80evk7x8un/. 
• Tolksdorf, Robert; Bontas, Elena Paslaru (2004). "Organizing Knowledge in a Semantic Web for Pathology". Object-Oriented and Internet-Based Technologies. Lecture Notes in Computer Science. 3263. pp. 115–56. doi:10.1007/978-3-540-30196-7_4. ISBN 978-3-540-23201-8. 
• Potts, Steven J. (2009). "Digital pathology in drug discovery and development: Multisite integration". Drug Discovery Today 14 (19–20): 935–41. doi:10.1016/j.drudis.2009.06.013. PMID 19596461. 
• Potts, Steven J.; Young, G. David; Voelker, Frank A. (2010). "The role and impact of quantitative discovery pathology". Drug Discovery Today 15 (21–22): 943–50. doi:10.1016/j.drudis.2010.09.001. PMID 20946967. 
• Zwonitzer, R; Kalinski, T; Hofmann, H; Roessner, A; Bernarding, J (2007). "Digital pathology: DICOM-conform draft, testbed, and first results". Computer Methods and Programs in Biomedicine 87 (3): 181–8. doi:10.1016/j.cmpb.2007.05.010. PMID 17618703. 

External links

Informative sites or links

• APIII (a national pathology informatics meeting's website with archived presentations and contact information for faculty)
• Pathology Visions (a national digital pathology conference)
• Association for Pathology Informatics
• Digital Pathology Association
• Digital Pathology Blog
• The Digital Pathology Wiki

Academic Digital Pathology Sites

• Welcome to Digital Pathology at Brown Medical School
• Holycross Cancer Center (Poland, Kielce) Pathomorphology Department virtual slides
• Digital Pathology Imaging Group at University of Pittsburgh Medical Center

System Vendors (Image Analysis, WSI robots, Virtual Microscopy Software, and/or PACS/Image management software)

• 3DHISTECH
• Accelrys Pipeline Pilot
• Aperio
• Apollo
• Aurora Interactive
• BioImagene
• CompuCyte
• CRi
• Definiens
• Hamamatsu Photonics
• HistoRx
• i-Path Diagnostics
• Indica Labs
• Leica Microsystems
• LLTech Light for Life Technologies
• MikroScan Technologies, Inc
• Olympus
• Omnyx
• Simagis Live by Smart Imaging Technologies
• SlidePath
• PathLogik
• Philips Digital Pathology
• Pixcelldata
• [1]
• Vision Microscopy
• Visiopharm
• VMscope

Other Digital Pathology Vendors

• Digital Pathology Consultants
• Flagship Biosciences

Other Relevant sites

• Digital Pathology
• Guidon Blog on whole slide image analysis
• OpenSlide — C library that provides a simple interface to read whole-slide images.
• AccelPath Digital Telepatholgy