Diphenylcyclopropenone

Diphenylcyclopropenone
IUPAC name 2,3-Diphenylcycloprop-2-en-1-one
Other names Diphencyprone; DPCP
Identifiers
CAS number	886-38-4 Y
PubChem	65057
ChemSpider	58568
UNII	I7G14NW5EC
Jmol-3D images	Image 1
SMILES O=C2C(=C2\c1ccccc1)\c3ccccc3
InChI InChI=InChI=1S/C15H10O/c16-15-13(11-7-3-1-4-8-11)14(15)12-9-5-2-6-10-12/h1-10H
Properties
Molecular formula	C15H10O
Molar mass	206.24 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Diphenylcyclopropenone (diphencyprone) is a topically administered drug intended for treating alopecia areata and alopecia totalis.

Mechanism of action

Diphenylcyclopropenone is believed to act as a local irritant, triggering a local sensitization. Thereby, it is thought to trigger an immune response that opposes the action of the autoreactive cells that otherwise are believed to cause hair loss.^[1]

Efficacy

A study of 41 patient showed a significant hair regrowth in 40% at 6 months, being sustained in two thirds of these after a 12-month-follow up-period.^[2]

References

1. ^ [1] Public summary of positive opinion for orphan designation of diphenylcyclopropenone for the treatment of alopecia totalis. European Medicines Agency. Document Date: London, 23 April 2009. Doc.Ref.:EMEA/COMP/428277/2006
2. ^ Sotiriadis, D.; Patsatsi, A.; Lazaridou, E.; Kastanis, A.; Vakirlis, E.; Chrysomallis, F. (2006). "Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata". Clinical and Experimental Dermatology 32 (1): 48–51. doi:10.1111/j.1365-2230.2006.02256.x.