- Channelome
-
The channelome, sometimes "ion channelome", is an expression used to describe the complete set of ion channels expressed in a biological tissue or organism. It is analogous to the genome, the metabolome (describing metabolites), the proteome (describing general protein expression), the microbiome etc. Characterization of the ion channelome can be performed by a wide variety of ion channel studying techniques ("channelomics") including patch clamp electrophysiology, PCR and immunohistochemistry.
References
- Barrett-Jolley, R., R. Lewis, et al. (2010). "The Emerging Chondrocyte Channelome." Frontiers in Membrane Physiology and Biophysics. http://www.frontiersin.org/membrane_physiology_and_biophysics/10.3389/fphys.2010.00135/abstract
- Cohen, B. E.; Grabe, M.; Jan, L. Y. (2003). "Answers and Questions from the KvAP Structures". Neuron 39 (3): 395–400. doi:10.1016/S0896-6273(03)00472-0. PMID 12895415.
- Randall, A.; Mcnaughton, N.; Green, P. (Aug 2006). "Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: conventional and automated patch clamp analysis". Pharmacological research : the official journal of the Italian Pharmacological Society 54 (2): 118–128. doi:10.1016/j.phrs.2006.03.005. ISSN 1043-6618. PMID 16675265.
- Gabashvili, S.; Sokolowski, H.; Morton, C.; Giersch, B. (Sep 2007). "Ion channel gene expression in the inner ear". Journal of the Association for Research in Otolaryngology : JARO 8 (3): 305–328. doi:10.1007/s10162-007-0082-y. ISSN 1525-3961. PMC 2538437. PMID 17541769. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2538437.
- Perraud, A. L.; Schmitz, C.; Scharenberg, A. M. (2006). Calcium signaling, ion channels and more. pp. 257–270. doi:10.1007/978-1-4020-4896-8_15.
Categories:- Ion channels
- Channelopathy
- Chemistry stubs
Wikimedia Foundation. 2010.
