Desmethoxyyangonin

Desmethoxyyangonin
Desmethoxyyangonin
Identifiers
CAS number 15345-89-8 N
PubChem 5273621
ChemSpider 4438012 YesY
ChEMBL CHEMBL254218 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C14H12O3
Molar mass 228.24 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Desmethoxyyangonin or 5,6-dehydrokawain is one of the six major kavalactones found in the Piper methysticum (kava) plant.

Pharmacology

Desmethoxyyangonin is a reversible inhibitor of monoamine oxidase B (MAO-B). It is able to increase dopamine levels in the nucleus accumbens. This may be the reason for the euphoria from Kava consumption.

Desmethoxyyangonin has marked activity on the induction of CYP3A23.[1]

References

  1. ^ Ma, Yuzhong; Karuna Sachdeva, Jirong Liu1, Michael Ford, Dongfang Yang, Ikhlas Khan, Clinton Chichester, Bingfang Yan (2004 November). "Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.". Drug Metabolism and Disposition 32 (11): 1317–1324. doi:10.1124/dmd.104.000786. PMID 15282211. 

See also