- Pamidronic acid
drugbox
IUPAC_name = (3-amino-1-hydroxy-1-phosphono-propyl)phosphonic acid
CAS_number = 40391-99-9
ATC_prefix = M05
ATC_suffix = BA03
PubChem = 4674
DrugBank = APRD01161
C = 3 | H = 11 | N = 1 | O = 7 | P = 2
molecular_weight = 235.07 g/mol
bioavailability = n/a
protein_bound = 54%
metabolism = Nil
elimination_half-life = 28 ± 7 hours
excretion = Renal
pregnancy_AU = B3
pregnancy_US = D
legal_AU =
legal_UK = POM
legal_US = Rx-only
routes_of_administration = IntravenousPamidronic acid (INN) or pamidronate disodium (USAN), pamidronate disodium pentahydrate is a nitrogen containing
bisphosphonate , used to preventosteoporosis . It is marketed byNovartis under the brand name Aredia.Uses
It is used to prevent
bone loss, and treatosteoporosis . It is also used to strengthen bone inPaget's disease , to prevent bone loss due to steroid use, and in certaincancer s with high propensity to bone, such asmultiple myeloma . In multiple myeloma, it is usually administered as an intravenous infusion, lasting about 3 hours. The therapy is repeated monthly, and lasts for the life of the patient. Due to its ability to sequestercalcium in bone, it is also used to treat high calcium levels.It is also used as an experimental treatment of the bone disorder known asOsteogenesis Imperfecta , or brittle bones.Administration
Intravenous , usually 90 mg monthly. 30 mg, 60 mg, and 90 mg vials are available, mixed withmannitol .ide effects
Common side effects include bone pain, low calcium levels,
nausea , anddizziness .Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including pamidronate.cite journal | author = Zarychanski R, Elphee E, Walton P, Johnston J | title = Osteonecrosis of the jaw associated with pamidronate therapy. | journal = Am J Hematol | volume = 81 | issue = 1 | pages = 73–5 | year = 2006 | pmid = 16369966 | doi = 10.1002/ajh.20481]Pamidronate activates human γδ T cells "
in vitro " and "in vivo ", which may lead to flu-like symptoms upon administration.References
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